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⭐Multiple Myeloma Hub spotlight: Mechanism of action for CELMoDs in MM ⭐
Cereblon E3 ligase modulating drugs (CELMoDs) are next-generation immunomodulatory drugs (IMiDs) designed to enhance protein degradation and immune activation in multiple myeloma. By binding to cereblon, they promote targeted protein degradation, stimulate T cell and NK cell responses, and overcome IMiD resistance, improving anti-myeloma efficacy.
This educational resource is independently supported by Bristol Myers Squibb. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource.